Investigating novel mechanisms of asthma and allergic lung inflammation

Dr. Taylor Doherty 

Taylor Alan Doherty

Dr. Taylor A. Doherty is an associate professor of medicine at UC San Diego.  His studies have led to high impact publications in the fields of asthma, airway remodeling, and type 2 innate lymphocyte function.

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About the Lab 

Initial work from the Doherty lab identified novel targets in airway inflammation and remodeling that occur during chronic asthma.  The lab has recently developed a focus on innate type 2 lung responses that may contribute to asthma and allergic disease.  We have identified novel mechanisms that regulate a recently discovered population of cells (type 2 innate lymphocytes) using animal models and human samples. 

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Research Highlights 

  •  Recent findings published in The Journal of Allergy and Clinical Immunology: Doherty TA, Scott D, et al.  Allergen challenge in allergic rhinitis rapidly induces increased peripheral blood type 2 innate lymphoid cells that express CD84.  
  • Previous work published in Nature Medicine:  Doherty TA, Soroosh P, et al.  The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodeling.  
  • Funding in the Doherty lab: National institute of Allergy and Infectious Disease (NIAID), American Lung Association (ALA), American Academy of Allergy, Asthma, and Immunology (AAAAI), and UCSD CTRI.