Identifying Mechanisms, Mediators and Clinical Effects of Esophageal Remodeling in Eosinophilic Esophagitis

Dr. Seema Aceves 

Seema Aceves, MD, PhDSeema Aceves, MD, PhD,  is associate professor of pediatrics and medicine at UC San Diego and director of the Eosinophilic Gastrointestinal Disorders Clinic at Rady Children's Hospital, San Diego. She received her medical degree, her pediatrics residency training and her allergy/immunology fellowship training at UC San Diego.

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About the Lab 

The Aceves lab conducts clinical and translational investigations of the impact and mechanisms of tissue remodeling on eosinophilic esophagitis (EoE). A disease of increasing worldwide prevalence, EoE is quickly becoming a significant healthcare burden. The Aceves Lab uses primary human esophageal cells as in vitro model systems to understand the mechanisms of epithelial, fibroblast and smooth muscle changes in EoE.

Research Highlights 

  • The Aceves Lab is in the second year of a five-year NIH/NIAID-funded R01 grant, Mechanisms of tissue damage leading to chronic allergic eosinophilic esophagitis, for which Dr. Aceves is principal investigator.
  • The most recent publication from Dr. Aceves and coworkers will be highlighted as an "Editor's Choice" article in the June issue of the Journal of Allergy and Clinical Immunology.
  • Dr. Aceves was elected to the American Society for Clinical Investigation this year.  |  Read news story
  • She has received the 2013 HOPE APFED /ARTrust™ Pilot Grant Award to Medical School Faculty to fund a two-year study of epithelial markers of esophageal remodeling.