Aladdin Shadyab, PhD.
Aladdin Shadyab, PhD. 7/16-present. Mentoring team: Primary Mentor: Andrea LaCroix, PhD. Co-mentors: Robert Terkeltaub, MD., Rany Salem, PhD. Project: Predictors of Healthy Aging and Late-Life Musculoskeletal Functional Outcomes in Postmenopausal Women: Sub-Studies of The Women’s Health Initiative.
Dr. Shadyab is uniquely qualified, with an Epidemiology PhD graduate of UCSD, with two additional Master's degrees (Biostatistics, Informatics), and undergraduate major in Biochemistry. He was recruited to the T32 with a learning plan to develop new skills sets in genetic epidemiology, biomarkers, and outcomes research highly pertinent to rheumatic diseases. Currently finishing his first year as a postdoctoral trainee, he is working integratively with UCSD Genetic Epidemiologist Rany Salem PhD, Dr. Terkeltaub, and others in Rheumatology on rheumatic disease-related projects as he fast tracks to NIH career development award applications and dual faculty appointment in Epidemiology and Rheumatology at UCSD or elsewhere.
Dr. Shadyab’s first set of T32 studies has examined the relationships of sedentary behavior and aging to poor functional outcomes in OA, focusing on women in the Women’s Health Initiative (WHI) cohort. Long-term functional outcomes of women who receive total hip (THR) or knee replacements (TKR), including late-life mobility and quality of life, have not been extensively studied. In prior studies, risk factors for poor functional outcomes (e.g., pain, poor health-related quality of life, activity limitation, impaired mobility) following THR and TKR have included obesity, depression, female gender, older age, and poor functional outcome pre-surgery. The majority of these studies were limited by small sample sizes and short follow-up periods (i.e., six months to one year), and limited data are currently available on late-life functional outcomes among THR and TKR patients. Furthermore, previous studies were exclusive to hospital-based cohorts, limiting generalizability of findings to the general population. The large number of women in the WHI who survived to “advanced old ages” presents a unique opportunity to evaluate predictors of late-life functional outcomes of postmenopausal women with THR and TKR. Dr.Shadyab’s work uniquely determines, among women diagnosed with OA who received THR or TKR, the predictors of functional musculoskeletal and related outcomes (including healthy aging, mobility, activities of daily living, self-rated health, quality of life, and joint pain and stiffness) at advanced old ages (85 and above, 90 and above, and 95 and above). WHI data have been linked with Centers for Medicare and Medicaid Services Data; 97% of Medicare-eligible WHI participants were successfully linked. His current studies focus on associations of BMI, waist circumference (WC), and waist-hip ratio (WHR) with mobility limitation and physical impairment at age 85 among women with total knee or hip replacement for OA, in prospective analyses of WHO cohort subjects. Dr. Shadyab, with Drs. LaCroix, Salem, and Terkeltaub, also is developing weighted genetic risk scores to examine the BMI-independent and physical activity-independent compound effects of inflammation-modulating SNPs on hip and knee OA, and also will carry out a unique Mendelian Randomization study.