Kim E. Barrett, PhD


Kim E. Barrett, PhD.
Professor of Medicine

Research Interests
  • The functional heterogeneity of mast cells from different organs and species.
  • The role of mast cells in allergic and inflammatory diseases.
  • Immune-related intestinal secretion.
  • Mechanisms of epithelial ion transport.
  • Pathophysiological consequences of enteric infections.
(Publications selected from 148 manuscripts)

  1. Kahn, M.E.S., A. Senderowicz, E.A. Sausville, and K.E. Barrett: Possible mechanisms of diarrheal side-effects associated with the use of a novel chemotherapeutic agent, flavopiridol. Clin. Cancer Res. 7: 343-349, 2001.
  2. Smitham, J .E. , and K. E. Barrett: Differential effects of apical and basolateral uridine triphosphate on intestinal chloride secretion: implications for cystic fibrosis. Am. J. Physiol. 280: C1431-C1439, 2001.
  3. Chang, N., J.M. Uribe, S.J. Keely, and K.E. Barrett: Insulin and IGF-I factor I inhibit calcium-dependent chloride secretion by T84 human colonic epithelial cells. Am. J. Physiol. 281: G129-G137, 2001.
  4. Zambon, A.C., B. Torres, K.E. Barrett, L.L. Brunton, and P.A. Insel. Cloning, expression, signaling mechanisms and membrane targeting of MDCK-D1 P2Y11 receptors. Mol. Pharmacol. 60: 26-35, 2001.
  5. Resta-Lenert, S., F. Truong, K.E. Barrett, and L. Eckmann. Inhibition of epithelial chloride secretion by butyrate: role of reduced adenylyl cyclase expression and activity. Am. J. Physiol. 281: C1837-C1849, 2001.
  6. Abreu, M.T., E. T. Arnold, J.Y.C. Chow, and K.E. Barrett. PI3'-kinase-dependent pathways oppose Fas-induced apoptosis and limit chloride secretion in human intestinal epithelial cells: implications for inflammatory diarrheal states. J. Biol. Chem. 276: 47563-47574, 2001.
  7. Resta-Lenert, S., and K.E. Barrett. Enteroinvasive bacteria alter barrier and transport properties of human intestinal epithelium: role of iNOS and COX-2. Gastroenterology 122: 1070-1087, 2002.
  8. Uribe, J.M., D.F. McCole, and K.E. Barrett. Interferon g activates the EGF receptor and increases TFGa in T84 cells: implications for chloride secretion. Am. J. Physiol. 283: G923-G931, 2002.
  9. McCole, D.F., S.J. Keely, R.J. Coffey, and K.E. Barrett. Transactivation of the epidermal growth factor in colonic epithelial cells by carbachol requires extracellular release of transforming growth factor-a. J. Biol. Chem. 277: 42603-42612, 2002.
  10. Keely, S.J., and K.E. Barrett. p38 mitogen-activated protein kinase inhibits calcium-dependent chloride secretion in T84 colonic epithelial cells. Am. J. Physiol. Cell Physiol. 284: C339-C348, 2003.
  11. Bertelsen, L.S., G. Paesold, L. Eckmann, and K.E. Barrett. Salmonella infection induces a hypersecretory phenotype in human intestinal xenografts by inducing cyclooxygenase-2. Infec. Immun. 71:2102-2109, 2003.
  12. Resta-Lenert, S., and K.E. Barrett: Live probiotics protect intestinal epithelial cells from the effects of infection with enteroinvasive E. coli (EIEC). Gut 52: 988-997,2003.
  13. Chow, J.Y.C., K. Carlstrom, and K.E. Barett: Growth hormone reduces chloride secretion in human epithelial colonic cells via EGF receptor and ERK1 / 2 MAPK. Gastroenterology 125: 1114-1124, 2003.
  14. Rao, S.P., Z. Sellers, D.L. Crombie, D.L. Hogan, E.A. Mann, D. Childs, S. Keely, M. Sheil-Puopolo, R.A. Gianella, K.E. Barrett, J.I. Isenberg, and V.S. Pratha: A role of guanylate cyclase C(GC-C) in acid-stimulated duodenal mucosal bicarbonate secretion. Am. J. Physiol. 286: G95-G101, 2004.
  15. Bertelsen, L.S., L. Eckmann, and K.E. Barrett: Prolonged interferon-g exposure decreases ion transport, NKCC-1 and NA+ , K+ ATPase expression in human intestinal xenografts in vivo. Am. J. Physiol. 286: G157-G165, 2004.
  16. Tuo, B-G, P. Paulus, Z. Sellers, K.E. Barrett, and J.I. Isenberg: 5-hydroxytryptamine4 receptors mediate 5-hydroxytryptamine-induced duodenal mucosal bicarbonate secretion in mice. Am. J. Physiol. 286: G444-G451, 2004.
  17. Tuo, B-G., J.Y.C. Chow, K.E. Barrett, and J.I. Isenberg: Protein kinase C potentiates cAMP-stimulated mouse duodenal mucosal bicarbonate secretion examined in vitro. Am. J. Physiol., G814-G821, 2004.
  18. Bertelsen, L.S., K.E. barrett, and S.J. Keely. Gs protein-coupled receptor agonists induce transactivation of the EGFr in T84 cells: implications for cAMP-dependent chloride secretion. J. Biol. Chem., 279: 6271-6279, 2004.
  19. Bertelsen, L.S. G. Paesold, S.L. Marcus, B.B. Finlay, L. Eckmann, and K.E. Barrett. Modulation of chloride secretory responses of intestinal epithelial cells by the Salmonella effector protein SigD. Am. J. Physiol. 287: C939-C949, 2004.