Kim E. Barrett, PhD

Barrett, Kim E., PhD

Kim E. Barrett, BSc, PhD
Distinguished Professor of Medicine
Dean of Graduate Studies

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Dr. Barrett received her Bachelor of Science with first class honors in medicinal chemistry and her PhD in biological chemistry at University College London, England.

Research Interests

  • The functional heterogeneity of mast cells from different organs and species
  • The role of mast cells in allergic and inflammatory diseases
  • Immune-related intestinal secretion
  • Mechanisms of epithelial ion transport 
  • Pathophysiological consequences of enteric infections

Clinic Focus and Practice

Dr. Barrett does not see patients.

Selected Publications

  1. Dong, X., K.H. Ko, J. Chow, B. Tuo, K.E. Barrett, and H. Dong: Expression of acid-sensing ion channels in intestinal epithelial cells and their role in the regulation of duodenal mucosal bicarbonate secretion. Acta Physiologica 201(1): 97-107, 2011 (PMID 20969730).
  2. Hoda, M.R., M. Scharl, S.J. Keely, D.F. McCole, and K.E. Barrett: Apical leptin induces chloride secretion by intestinal epithelial cells and in a rat model of acute chemotherapy-induced colitis. Am. J. Physiol.: GI Liver Physiology 298: G714-G721, 2010 (PMCID 2867420).
  3. Harmon, G.S., D.S. Dumlao, D. T. Ng, K.E. Barrett, E.A. Dennis, H. Dong, and C.K. Glass: Pharmacologic correction of a defect in PPARγ signaling ameliorates disease severity in Cftr-deficient mice. Nature Medicine 16 (3): 313-318, 2010 (PMCID 20154695).
  4. Scharl, M., K.E. Barrett and D.F. McCole: Protection of epithelial barrier function by the Crohn’s disease associated gene, protein tyrosine phosphatase N2. Gastroenterology 137: 2030-2040, 2009 (PCMID: PMC2855721). 
  5. Scharl, M., K.E. Barrett, and D.F. McCole: Adenosine monophosphate activated protein kinase mediates the interferon γ-induced decrease in intestinal epithelial barrier function. J. Biol. Chem 284 (41): 27952-27963, 2009 (PMCID19654324). 
Additional Barrett Publications via PubMed