Dr. Hoffman received his BA (biology) at Wesleyan University in Middletown, Connecticut, and his MD (Medicine) at the University of Texas Medical Branch in Galveston, Texas.
Regulation of cytokines and inflammation by cryopyrin. Research focus on the genetics of inflammatory disorders, positional cloning of target genes and the function of such genes in the expression of inflammation.
Sivagnanam M, Mueller JL, Lee H, Chen Z, Nelson SF, Turner D, Zlotkin SH, Pencharz PB, Ngan BY, Libiger O, Schork NJ, Lavine JE, Taylor S, Newbury RO, Kolodner RD, Hoffman HM (2008) Identification of EpCAM as the Gene for Congenital Tufting Enteropathy. Gastroenterology. 135: 2: 429-37 PMCID: PMC2574708.
Anderson JP, Mueller JL, Misaghi A, Anderson S, Sivagnanam M, Kolodner RD, Hoffman HM (2008). Initial description of the human NLRP3 promoter. Genes Immun, 9: 8: 721-6. PMID: 18719602 PMC Journal – In Process.
Brydges SD, Mueller JL, McGeough MD, Pena CA, Misaghi A, Gandhi C, Putnam CD, Boyle DL, Firestein GS, Horner AA, Soroosh P, Watford WT, O'Shea JJ, Kastner DL, Hoffman HM (2009). Animal Models of Inflammasomopathies Reveal Roles for Innate but not Adaptive Immunity. Immunity, 30: 6: 875-87. PMID: 19501000 PMC Journal – In Process.
Gandhi C, Healy C, Wanderer AA, Hoffman HM (2009). Familial atypical cold urticaria: description of a new hereditary disease. J Allergy Clin Immunol. 124(6):1245-50. PMID: 19910034 PMC Journal – In Process.
Hoffman HM, Scott P, Mueller JL, Misaghi A, Stevens S, Yancopoulos GD, Murphy A , Valenzuela DM, Liu-Bryan R, (2010) “Role of the Leucine-rich Repeat (LRR) Domain of Cryopyrin/NALP3 in Monosodium Urate Crystal-induced Inflammation,” Arthritis Rheum 62:7: 2170-9.
Additional Hoffman Publications via PubMed