Eyal Raz, MD

Eyal Raz, MD

Eyal Raz, MD
Professor of Medicine

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Dr. Eyal Raz, Professor of Medicine in the University of California San Diego, received his MD degree in 1980 from the Hebrew University at the Hadassah Medical School in Jerusalem, Israel.
The current research in his laboratory focuses on the fundamentals of host interactions with environmental factors. His team studies host response to microbial Toll-like receptor (TLR) and the non-TLR stimulation. In addition they explore the role of members of the Transient receptor potential (TRP) family by which the host interacts with diverse chemical and biochemical originate from the environment.
His laboratory explores the consequences of these host-environmental interactions on the induction of inflammatory processes and immune responses in the affected host. These include vaccines design against various infectious agents, modulation of allergic diseases, inflammatory bowel diseases and cancer.

 

Research Interests

  • Fundamentals of innate immunity
  • TLR and the non-TLR activation pathways

The research in my lab is focusing on the fundamentals of innate immunity. We study the Toll-like receptor (TLR) and the non-TLR activation pathways by which the host recognizes and responds to any microbial agent. We explore the consequences of this activation on antigen presentation by dendritic cells and its impact on priming of naïve CD4 and CD8 T cells as well as the generation of memory T cell responses.

Using a similar strategy, we investigate the role of transient receptor potential (TRP) family members in inflammation. This approach to basic science helps us to develop vaccines against various infectious agents (e.g., HIV), tumors and allergic diseases (i.e., asthma). Some of the therapeutic approaches developed in our lab are already used in humans.

Similarly, we explore the role of innate immunity in the inhibition of certain inflammatory conditions. In particular, we study the principles of host-commensal interaction in the G-I tract and explore how this interaction affects various inflammatory intestinal conditions and their human analogs such as inflammatory bowel disease and colitis-associated cancer.

Selected Publications

 

  1. Sato Y, Roman M, Tighe H, Lee D, Corr M, Nguyen M-D, Silverman GJ, Lotz M, Carson DA, Raz E. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science 1996 273:352-4.
  2. Roman M, Martin-Orozco E, Goodman J, Nguyen MD, Sato Y, Ronaghy A, Kornbluth R, Richman DD, Carson DA, Raz E, Immunostimulatory DNA sequences function as Th1 promoting adjuvants. Nature Medicine 1997 3:849-54. Hayashi T, Beck L, Rossetto C, Gong X, Takikawa O, Takabayashi K, Broide B, Carson DA and Raz E. Inhibition of experimental asthma by indoleamine 2,3-dioxygenase. J Clin Invest 114:270-279, 2004.
  3. Lee J, Mo JH, Katakura K, Alkalay I, Rucker AN, Liu YT, Lee HK, Shen C, Cojocaru G, Shenouda S, Kagnoff M, Eckmann L, Ben-Neriah Y, Raz E. Maintenance of colonic homeostasis by distinct apical TLR9 signaling in intestinal epithelial cells. Nat Cell Biol 2006 8:1327-36. 
  4. Datta SK, Okamoto S, Hayashi T, Shin S, Fermin A, Fierer J and Raz E. Irradiated Listeria: a vaccination strategy for induction of protective T cell immunity.  Immunity 25:143-152, 2006.
  5. Hayashi T, Mo J-H, Gong X, Rossetto R, Jang A, Beck L, Elliott G, Ikufareva I, Abagyan R, Broide D, Lee J, and Raz E. 3-Hydroxyanthranilic acid, inhibits PDK1 activation and suppressed experimental asthma by inducing T cell apoptosis. Proc Natl Acad Sci USA 104:18619-18624, 2007. 
  6. Raz E. Regulation of organ-specific innate immunity. Nat Immunol 8:3-4, 2007.
  7. González-Navajas JM, Fine S, Law J, Datta SK. Nguyen KP, Yu M, Corr M, Katakura K, Eckmann L, Lee J, Raz E. TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice. J Clin Invest 2010 120:570-81. 
  8. Lee SH, Hu LL, Gonzalez-Navajas J, Seo GS, Shen C, Brick J, Herdman S, Varki N, Corr M, Lee J, Raz E. ERK activation drives intestinal tumorigenesis in APCmin/+ mice. Nat Med 2010 16:665-70. 
  9. Gonzalez-Navajas JM, Law J, Nguyen KP, Bhargava M, Corr MP, Varki N, Eckmann L, Hoffman HM, Lee J, Raz E. Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production. J Exp Med 2010 207:2799-807.  
  10. Gonzalez-Navajas JM, Lee J, David M, Raz E. Immunomodulatory functions of type 1 interferons. Nat Rev Immunol 2012, 12:125-135.

 

More Raz Publications via PubMed