• 1972 - B.S. (Medical Sciences), University of California, San Francisco
• 1974 - M.D. (Medicine), University of California, San Francisco
• 1979 - B.A. (Biochemistry), University of California, San Diego

• 1974 - 1975: Intern in Medicine
• Barnes Hospital, St. Louis, Missouri
• 1975 - 1976: Resident in Medicine
• Barnes Hospital, St. Louis, Missouri
• 1976 - 1979: Research Associate, Laboratory of Immunology
• NIAID-NIH, Bethesda, Maryland
• 1979 - 1981: Rheumatology Fellow
• University of California, San Diego
• 1981 - 1988: Assistant Professor of Medicine in Residence
• University of California, San Diego
• 1988 - 1989: Associate Professor of Medicine in Residence
• University of California, San Diego
• 1989 - 1992: Assistant Professor of Medicine
• University of California, San Diego
• 1992 - Present: Associate Professor of Medicine
• University of California, San Diego
• 1999 - Present: Director, Arthritis Outpatient Clinic
• UCSD Medical Center, San Diego
• 2000 - Present: Chair, Minor Proposition, Biomedical Sciences Graduate Program
• University of California, San Diego
• 2005 - Present: Professor of Medicine
• University of California, San Diego

• Rheumatology
• Internal Medicine

• UCSD Thornton Hospital, La Jolla
• UCSD Medical Center, Hillcrest

• Journal of the American Society for Mass Spectrometry
• Rapid Communications in Mass Spectrometry
• Public Library of Science: Computational Biology
• Chemical Reviews
• Journal of Biological Chemistry
• Current Medicinal Chemistry
• Protein Science
• Expert Opinion on Drug Discovery
• Journal of Molecular Biology
• Arthritis and Rheumatism
• Biochemistry
• Bioinformatics
• Molecular Pharmacology
  

• American Academy for the Advancement of Science
• American Chemical Society
• American College of Rheumatology
• Alpha Omega Alpha Medical Society, U.C. San Francisco Medical Center
• American Society of Hematology
• American Heart Association, Council on Thrombosis
• Protein Society
• American Society of Mass Spectrometry

• 2001 - Present: Grant Reviewer, Innovative Technologies for the Molecular Analysis of Cancer (IMAT) Study Section for NCI, NIH
• 2002 - Present: Grant Reviewer, University of California Industry - Univ. Coop. Research Program
• 2003 - Present: Applicant Interviewer for Department of Medicine Residency Program
• 2003 - 2006: UCSD Representative to the Research Council of the University of California - Industry Cooperative Research Program
• 2005 - Present: Grant Reviewer, National Science Foundation
• 2006 - Present: Grant Reviewer, American Institute for Biological Sciences
• 2006 - Present: Grant Reviewer, Biological Chemistry and Macromolecular Biophysics IRG, for NIH

(Publications selected from a total of 120 papers)

1.       Hamuro, Y, LL Burns, JM Canaves, RC Hoffman, SS Taylor, and VL Woods Jr. Domain Organization of D-AKAP2 Revealed by Enhanced Deuterium Exchange-Mass Spectrometry (DXMS). J Mol Biol 321:4, 703-714, 2002.

2.       Hamuro, Y, L Wong, J Shaffer, JS Kim, DD Stranz, PA Jennings, VL Woods Jr and JA Adams. Phosphorylation-Driven Motion in the COOH-Terminal Src Kinase, Csk, Revealed through Enhanced Hydrogen-Deuterium Exchange and Mass Spectrometry (DXMS). J Mol Biol 323:5 871-881, 2002.

3.       Hamuro, Y, KM Zawadzki, JS Kim, DD Stranz, SS Taylor, and VL Woods Jr. Dynamics of cAPK Type IIb Activation Revealed by Enhanced Amide H/2H Exchange Mass Spectrometry (DXMS). J Mol Biol 327:5 1065-1076, 2003.

4.       Englander, JJ, C Del Mar, W Li, SW Englander, JS Kim, DD Stranz, Y Hamuro and VL Woods Jr. Protein structure change studied by hydrogen-deuterium exchange, functional labeling,and mass spectrometry. Proc Natl Acad Sci USA Jun 10: 100(12):7057-62, 2003.

5.       Zawadzki, KM, Y Hamuro, JS Kim, S Garrod, DD Stranz, SS Taylor, and VL Woods Jr. Dissecting interdomain communication within cAPK regulatory subunit tyoe IIbeta using enhanced amide hydrogen/deuterium exchange mass spectrometry (DXMS). Protein Sci Sept 12(9): 1980-90, 2003.

6.       Pantazatos, D, JS Kim, HE Klock, RC Stevens, IA Wilson, SA Lesley, and VL Woods Jr. Rapid Refinement of Crystallographic Protein Contruct Definition Employing Enhanced Hydrogen/ Deuterium Exchange Mass Spectrometry (DXMS). Proc Natl Acad Sci USA Jan 20: 101(3):751-56, 2004.

7.       Wong, L, S Lieser, B Chie-Leon, O Miyashita, B Aubol, J Shaffer, JN Onuchic, P Jennings, VL Woods Jr and JA Adams. Dynamic Coupling Between the SH2 Domain and Active Site of the COOH Terminal Src Kinase Csk. Journal of Molecular Biology, J Mol Biol., 341: 93-106, 2004.

8.       Hamuro,Y, GS Anand, JS Kim, C Juliano, DD Stranz, SS Taylor, and VL Woods Jr. Mapping Intersubunit Interactions of the Regulatory Subunit (RIa) in the Type I Holoenzyme of Protein Kinase A by Amide Hydrogen/ Deuterium Exchange Mass Spectrometry (DXMS). J Mol Biol., 340: 1185-1196, 2004.

9.       Black, B E, DR Foltz, S Chakravarthy, K Luger, VL Woods Jr and DW Cleveland. Structural Determinants for Generating Centromeric Chromatin. Nature 430: 578-582, 2004.

10.    Spraggon, G., D. Pantazatos, H.E. Klock, I.A. Wilson, V.L. Woods, Jr., and S.A. Lesley. On the use of DXMS to produce more crystallizable proteins: structures of the T. maritima proteins TM0160 and TM1171. Protein Sci 13:3187-3199, 2004.

11.    Burns-Hamuro, L.L., Y. Hamuro, J.S. Kim, P. Sigala, R. Fayos, D.D. Stranz, P.A. Jennings, S.S. Taylor, and V.L. Woods, Jr. Distinct interaction modes of an AKAP bound to two regulatory subunit isoforms of protein kinase A revealed by amide hydrogen/deuterium exchange. Protein Sci 14:2982-2992, 2005.

12.    Del Mar, C., E.A. Greenbaum, L. Mayne, S.W. Englander, and V.L. Woods, Jr. Structure and properties of alpha-synuclein and other amyloids determined at the amino acid level. Proc Natl Acad Sci U S A 102:15477-15482, 2005.

13.    Derunes, C., K. Briknarova, L. Geng, S. Li, C.R. Gessner, K. Hewitt, S. Wu, S. Huang, V.I. Woods, Jr., and K.R. Ely. Characterization of the PR domain of RIZ1 histone methyltransferase. Biochem Biophys Res Commun 333:925-934., 2005.

14.    Garcia, R.A., D.P. Pantazatos, C.R. Gessner, K.V. Go, V.L. Woods, Jr., and F.J. Villarreal. Molecular interactions between matrilysin and the matrix metalloproteinase inhibitor doxycycline investigated by deuterium exchange mass spectrometry. Mol Pharmacol 67:1128-1136, 2005.

15.    Iyer, G.H., S. Garrod, V.L. Woods, Jr., and S.S. Taylor. Catalytic independent functions of a protein kinase as revealed by a kinase-dead mutant: study of the Lys72His mutant of cAMP-dependent kinase. J Mol Biol 351:1110-1122, 2005.

16.    Kambo, A., V.S. Sharma, D.E. Casteel, V.L. Woods, Jr., R.B. Pilz, and G.R. Boss. Nitric oxide inhibits mammalian methylmalonyl-CoA mutase. J Biol Chem 280:10073-10082, 2005.

17.    Wong, L., S.A. Lieser, O. Miyashita, M. Miller, K. Tasken, J.N. Onuchic, J.A. Adams, V.L. Woods, Jr., and P.A. Jennings. Coupled motions in the SH2 and kinase domains of Csk control Src phosphorylation. J Mol Biol 351:131-143, 2005.

18.    Yang, J., S.M. Garrod, M.S. Deal, G.S. Anand, V.L. Woods, Jr., and S. Taylor. Allosteric network of cAMP-dependent protein kinase revealed by mutation of Tyr204 in the P+1 loop. J Mol Biol 346:191-201, 2005.

19.    Begley, M.J., G.S. Taylor, M.A. Brock, P. Ghosh, V.L. Woods, and J.E. Dixon. Molecular basis for substrate recognition by MTMR2, a myotubularin family phosphoinositide phosphatase. Proc Natl Acad Sci U S A 103:927-932, 2006.

20.    Brudler, R., C.R. Gessner, S. Li, S. Tyndall, E.D. Getzoff, and V.L. Woods, Jr. PAS domain allostery and light-induced conformational changes in photoactive yellow protein upon I2 intermediate formation, probed with enhanced hydrogen/deuterium exchange mass spectrometry. J Mol Biol 363:148-160, 2006.

21.    Derunes, C., R. Burgess, E. Iraheta, R. Kellerer, K. Becherer, C.R. Gessner, S. Li, K. Hewitt, K. Vuori, E.B. Pasquale, V.L. Woods, Jr., and K.R. Ely. Molecular determinants for interaction of SHEP1 with Cas localize to a highly solvent-protected region in the complex. FEBS Lett 580:175-178, 2006.

22.    Melnyk, R.A., K.M. Hewitt, D.B. Lacy, H.C. Lin, C.R. Gessner, S. Li, V.L. Woods, Jr., and R.J. Collier. Structural determinants for the binding of anthrax lethal factor to oligomeric protective antigen. J Biol Chem 281:1630-1635, 2006.

23.    Morris, T.A., J.J. Marsh, P.G. Chiles, W.R. Auger, P.F. Fedullo, and V.L. Woods, Jr. Fibrin derived from patients with chronic thromboembolic pulmonary hypertension is resistant to lysis. Am J Respir Crit Care Med 173:1270-1275, 2006.

24.    Black, B.E., M.A. Brock, S. Bedard, V.L. Woods, Jr., and D.W. Cleveland. An epigenetic mark generated by the incorporation of CENP-A into centromeric nucleosomes. Proc Natl Acad Sci U S A 104:5008-5013, 2007.

25.    Golynskiy, M., S. Li, V.L. Woods, Jr., and S.M. Cohen. Conformational studies of the manganese transport regulator (MntR) from Bacillus subtilis using deuterium exchange mass spectrometry. J Biol Inorg Chem, Mar 7, 2007.

26.    Morris, T.A., J.J. Marsh, P.G. Chiles, N.H. Kim, K.J. Noskovack, M.M. Magana, R.A. Gruppo, and V.L. Woods, Jr. Abnormally sialylated fibrinogen gamma-chains in a patient with chronic thromboembolic pulmonary hypertension. Thromb Res 119:257-259, 2007.

27.    Woods, VL Jr. and Y Hamuro. High resolution, high throughput amide deuterium exchange-mass spectrometry (DXMS) determination of protein binding site structure and dynamics: Utility in pharmaceutical design. J Cellular Biochem 37: 89-98. 2001.

28.    Hamuro,Y, S.J.Coales, and V. Woods. Protein-targeting Drug Discovery Guided by Hydrogen/Deuterium Exchange Mass Spectrometry (DXMS). In: Mass Spectrometry in Medicinal Chemistry, Chapter 12. K. Wanner and G. Hofner. Eds V36 of Methods and Principles in Medicinal Chemistry. Wiley-VCH. 2007.

29.    Brock, M., F. Fan, F.C. Mei, S. Li, C. Gessner, V.L. Woods, Jr., and X. Cheng. 2007. Conformational analysis of epac activation using amide hydrogen/deuterium exchange mass spectrometry. J Biol Chem 282:32256-32263. (V. Woods co-corresponding author)

30.     Broderick, K.E., L. Alvarez, M. Balasubramanian, D.D. Belke, A. Makino, A. Chan, V.L. Woods, Jr., W.H. Dillmann, V.S. Sharma, R.B. Pilz, T.D. Bigby, and G.R. Boss. 2007. Nitrosyl-cobinamide, a new and direct nitric oxide releasing drug effective in vivo. Exp Biol Med (Maywood) 232:1432-1440.

31.     Li, J., M.S. Lim, S. Li, M. Brock, M.S. Pique, V.L.J. Woods, and L. Craig. 2008. Vibro Cholerae Toxin-Coregulated Pilus Structure by Hydrogen/Deuterium Exchange Mass Spectrometry. Structure (Cell) 16(1):137-8  (V. Woods co-corresponding author)

32.     Hsu, Y.H., J.E. Burke, D.L. Stephens, R.A. Deems, S. Li, K.M. Asmus, V.L. Woods, Jr., and E.A. Dennis. 2008. Calcium binding rigidifies the C2 domain and the intra-domain interaction of GIVA phospholipase A2 as revealed by hydrogen/deuterium exchange mass spectrometry. J Biol Chem, in press, 2008. (V. Woods co-corresponding author).

1. Woods, VL Jr. Method for characterization of the fine structure of protein binding sites. U.S. Patent #5,658,739, issued August 19, 1997.
2. W2. Woods, VL Jr. Methods for the high-resolution identification of solvent-accessible amide hydrogens in polypeptides or proteins and for the characterization of the fine structure of protein binding sites. U.S. Patent #6.291.189, issued September 18, 2001.
3. Woods, VL Jr. Method for characterization of the fine structure of protein binding sites by amide hydrogen exchange. U.S. Patent #6.331.400, issued December 18, 2001.
4. Woods, VL Jr. Methods for identifying hot- spot residues of binding proteins and small compounds that bind to the same. U.S. Patent #6,599,707, issued July 29, 2003.
5. Woods, V.L., Jr. Methods for crystallographic structure determination employing hydrogen exchange analysis. U.S. Patent Application 2004/0153256, published August 5, 2004, claims allowed, June 2007.
6. Woods, VL Jr. Methods for the high-resolution identification of solvent accessible amide hydrogens in protein binding sites U.S. Patent #6,797,482, issued September 28, 2004.
7. Woods,V.L.,Jr., D.Pantazatos, P. Bourne, V. Hilser, H. White. Methods for the determination of protein three- dimensional structure employing hydrogen exchange analysis to refine computational structure prediction. PCT Patent Application WO 2005/044087, published May 19, 2005.
8. Woods,V.L., Jr. Methods for high-resolution identification of solvent accessible amide hydrogens in polypeptides and for characterization of polypeptide structure. U.S. Patent Application 2005/0233406, published October 20, 2005.
9. Woods,V.L., Jr., and S. Lesley. Enhanced methods for crystallographic structure determination employing hydrogen exchange analysis. U.S. Patent Application 2006/0166273 filed July 27, 2006.