9500 Gilman Drive, Room 181
La Jolla, CA 92093-0726
Tel: (858) 822-6432
Fax: (858) 822-6458
E-mail: mhginsberg@ucsd.edu

Lab website:   http://pstp.ucsd.edu/ginsberg/

• 1965 - (Psychology), McGill University, Montreal, Canada
• 1970 - M.D. Summa cum laude (Medicine), State University of New York, Down State Medical Center

• 1970 - 1975: USPHS trainee in Rheumatology, Dept. of Medicine; Intern/Resident in Internal Medicine
  • University of Chicago, IL
• 1975 - 2001: Professor; Assoc. Member; Dept. of Vascular Biology; Assoc. Member; Assist Member II; Assoc. Member I; Research Assoc., Department of Immunology; Postdoctoral Fellow, Dept of Allergy and Immunology and Immunopathology
  • The Scripps Research Institute
• 2001 - 2004: Professor, Department of Cell Biology, Division of Vascular Biology
  • The Scripps Research Institute
• 1992 - 2004: Adjunct Professor
  • UCSD School of Medicine, San Diego, CA.
• 2004 - present: Professor, Department of Medicine
  • University of California, San Diego

• Internal Medicine
• Rheumatology

• UCSD Thornton Hospital, La Jolla
• UCSD Medical Center, Hillcrest

• 1991 - 1995: Editorial Board, Journal of Biological Chemistry
• 1992 - 1996: NIH Pathobiochemistry Study Section, Thrombosis and Hemostaesis
• 1996 - Present: Editorial Board, Trends in Cardiovascular Medicine
• 1992 - 1997: Associate Editor, Journal of Clinical Investigation
• 1997 - 2002: Editorial Board, Journal of Biological Chemistry
• 2000 - 2004: Hematology Study Section
• 2007-2011: Intracellular Interactions Study Section
• 2007-2008: President, North American Vascular Biology Organization
• Present: ASCI, AFCR, AAI, ASCB, AAP

1. 1. Lee, H.S., Lim, C.J., Puzon-McLaughlin, W., Shattil, S.J., and Ginsberg, M.H. 2008. RIAM activates integrins by linking talin to Ras GTPase membrane-targeting sequences. J Biol Chem In Press.

   2. Glading, A., Han, J., Stockton, R.A., and Ginsberg, M.H. 2007. KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions. J Cell Biol 179:247-254.

   3. Goldfinger, L.E., Ptak, C., Jeffery, E.D., Shabanowitz, J., Han, J., Haling, J.R., Sherman, N.E., Fox, J.W., Hunt, D.F., and Ginsberg, M.H. 2007. An Experimentally Derived Database of Candidate Ras-Interacting Proteins. J Proteome.Res 6:1806.

   4. Lim, C.J., Han, J., Yousefi, N., Ma, Y., Amieux, P.S., McKnight, G.S., Taylor, S.S., and Ginsberg, M.H. 2007. alpha4 Integrins are Type I cAMP-dependent protein kinase-anchoring proteins. Nat Cell Biol 4:415.

   5. Petrich, B.G., Fogelstrand, P., Partridge, A.W., Yousefi, N., Ablooglu, A.J., Shattil, S.J., and Ginsberg, M.H. 2007. The antithrombotic potential of selective blockade of talin-dependent integrin alphaIIbbeta3 (platelet GPIIb-IIIa) activation. Journal of Clinical Investigation 117:2250-2259.

   6. Prager, G.W., Feral, C.C., Kim, C., Han, J., and Ginsberg, M.H. 2007. CD98hc (SLC3a2) interaction with the integrin beta subunit cytoplasmic domain mediates adhesive signaling. J Biol Chem. 282:24477-24484.

   7. Jones, C.A., London, N.R., Chen, H., Park, K.W., Sauvaget, D., Stockton, R.A., Wythe, J.D., Suh, W., Larrieu-Lahargue, F., Mukouyama, Y.S., et al. 2008. Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability. Nat Med 14:448-453.

   8. Goldfinger, L.E., Tzima, E., Stockton, R., Kiosses, W.B., Kinbara, K., Tkachenko, E., Gutierrez, E., Groisman, A., Nguyen, P., Chien, S., et al. 2008. Localized alpha4 Integrin Phosphorylation Directs Shear Stress-Induced Endothelial Cell Alignment. Circ Res 103:177-185.

   9. Watanabe, N., Bodin, L., Pandey, M., Krause, M., Coughlin, S., Boussiotis, V.A., Ginsberg, M.H., and Shattil, S.J. 2008. Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3. J Cell Biol 181:1211-1222.

   10. Feral, C.C., Neels, J.G., Kummer, C., Slepak, M., Olefsky, J.M., and Ginsberg, M.H. 2008. Blockade of alpha4 integrin signaling ameliorates the metabolic consequences of high-fat diet-induced obesity. Diabetes 57:1842-1851.

   11. Lim, C.J., Kain, K.H., Tkachenko, E., Goldfinger, L.E., Gutierrez, E., Allen, M.D., Groisman, A., Zhang, J., and Ginsberg, M.H. 2008. Integrin-mediated protein kinase A activation at the leading edge of migrating cells. Mol Biol Cell 19:4930-4941.

   12. Wegener, K.L., Partridge, A., Han, J., Pickford, A.R., Liddington, R.C., Ginsberg, M.H., and Campbell, I.D. 2007. Structural basis of integrin activation by talin. Cell 128:171.

   13. Petrich, B.G., Marchese, P., Ruggeri, Z.M., Spiess, S., Weichert, R.A., Ye, F., Tiedt, R., Skoda, R.C., Monkley, S.J., Critchley, D.R., et al. 2007. Talin is required for integrin-mediated platelet function in hemostasis and thrombosis. J Exp Med 204:3103-3111.

   14. Feral, C.C., Zijlstra, A., Tkachenko, E., Prager, G., Gardel, M.L., Slepak, M., and Ginsberg, M.H. 2007. CD98hc (SLC3A2) participates in fibronectin matrix assembly by mediating integrin signaling. J Cell Biol 178:701-711.

   15. Feral, C.C., Rose, D.M., Han, J., Fox, N., Silverman, G.J., Kaushansky, K., and Ginsberg, M.H. 2006. Blocking the alpha 4 integrin-paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site. J Clin.Invest 116:715.

   16. Goldfinger, L.E., Ptak, C., Jeffery, E.D., Shabanowitz, J., Hunt, D.F., and Ginsberg, M.H. 2006. RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration. J Cell Biol 174:877.

   17. Han, J., Lim, C.J., Watanabe, N., Soriani, A., Ratnikov, B., Calderwood, D.A., Puzon-McLaughlin, W., Lafuente, E.M., Boussiotis, V.A., Shattil, S.J., et al. 2006. Reconstructing and Deconstructing Agonist-Induced Activation of Integrin alphaIIbbeta3. Curr.Biol 16:1796.

   18. Lee, J., Hong, J., Nam, T.G., Peters, E.C., Orth, A.P., Geierstanger, B.H., Goldfinger, L.E., Ginsberg, M.H., Cho, C.Y., and Schultz, P.G. 2008. A small molecule inhibitor of alpha4 integrin-dependent cell migration. Bioorg Med Chem.

   19. Alon, R., Feigelson, S.W., Manevich, E., Rose, D.M., Schmitz, J., Overby, D.R., Winter, E., Grabovsky, V., Shinder, V., Matthews, B.D., et al. 2005. alpha4beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4-cytoplasmic domain. J Cell Biol 171:1073.

   20. Arias-Salgado, E.G., Lizano, S., Shattil, S.J., and Ginsberg, M.H. 2005. Specification of the direction of adhesive signaling by the integrin beta cytoplasmic domain. J Biol Chem. 280:29699.

   21. Nishiya, N., Kiosses, W.B., Han, J., and Ginsberg, M.H. 2005. An [alpha]4 integrin-paxillin-Arf-GAP complex restricts Rac activation to the leading edge of migrating cells. Nat Cell Biol 4:343.

   22. Partridge, A.W., Liu, S., Kim, S., Bowie, J.U., and Ginsberg, M.H. 2005. Transmembrane domain helix packing stabilizes integrin alpha IIbbeta 3 in the low affinity state. J Biol Chem. 280:7294.

   23. Ratnikov, B., Ptak, C., Han, J., Shabanowitz, J., Hunt, D.F., and Ginsberg, M.H. 2005. Talin phosphorylation sites mapped by mass spectrometry. J Cell Sci 118:4921.

   24. Feral, C.C., Nishiya, N., Fenczik, C.A., Stuhlmann, H., Slepak, M., and Ginsberg, M.H. 2004. CD98hc (SLC3A2) mediates integrin signaling. Proc.Natl.Acad.Sci U.S.A 102:355.

   25. Calderwood, D.A., Fujioka, Y., de Pereda, J.M., Garcia-Alvarez, B., Nakamoto, T., Margolis, B., McGlade, C.J., Liddington, R.C., and Ginsberg, M.H. 2003. Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: A structural prototype for diversity in integrin signaling. Proceeding of the National Academy of Science of the United States of America 100:2272.

   26. Chou, F.L., Hill, J.M., Hsieh, J.C., Pouyssegur, J., Brunet, A., Glading, A., Uberall, F., Ramos, J.W., Werner, M.H., and Ginsberg, M.H. 2003. PEA-15 binding to ERK1/2 MAP kinases is required for its modulation of integrin activation. J Biol Chem. 278:52587.

   27. Garcia-Alvarez, B., de Pereda, J.M., Calderwood, D.A., Critchley, D.R., Ulmer, T.S., Campbell, I.D., Ginsberg, M.H., and Liddington, R.C. 2003. Structural Determinants of Integrin Interaction with Talin. Mol.Cell 11:49.

   28. Goldfinger, L.E., Han, J., Kiosses, W.B., Howe, A.K., and Ginsberg, M.H. 2003. Spatial restriction of alpha4 integrin phosphorylation regulates lamellipodial stability and alpha4beta1-dependent cell migration. J Cell Biol 162:731.

   29. Han, J., Rose, D.M., Woodside, D.G., Goldfinger, L.E., and Ginsberg, M.H. 2003. Integrin alpha4 beta1-dependent T cell migration requires both phosphorylation and de-phosphorylation of the alpha4 cytoplasmic domain to regulate the reversible binding of paxillin. J Biol Chem. 278:34845.

   30. Rose, D.M., Liu, S., Woodside, D.G., Han, J., Schlaepfer, D.D., and Ginsberg, M.H. 2003. Paxillin Binding to the alpha4 integrin subunit stimulates LFA-1 (Integrin alphaLbeta2)-dependent T Cell migration by augmenting the activation of focal adhesion kinase/proline-rich tyrosine kinase-2. The Journal of Immunology 170:5912.

   31. Tadokoro, S., Shattil, S.J., Eto, K., Tai, V., Liddington, R.C., de Pereda, J.M., Ginsberg, M.H., and Calderwood, D.A. 2003. Talin binding to integrin tails: a final common step in integrin activation. Science 302:103.

   32. Ulmer, T.S., Calderwood, D.A., Ginsberg, M.H., and Campbell, I.D. 2003. Domain-Specific Interactions of Talin with the Membrane-Proximal Region of the Integrin beta3 Subunit. Biochemistry 42:8307.

   33. Calderwood, D.A., Yan, B., de Pereda, J.M., Garcia-Alvarez, B., Fujioka, Y., Liddington, R.C., and Ginsberg, M.H. 2002. The phosphotyrosine binding (PTB)-like domain of talin activates integrins. Journal of Biological Chemistry 277:21749.

   34. Calderwood, D.A., Huttenlocher, A., Kiosses, W.B., Schwartz, M.A., and Ginsberg, M.H. 2001. Increased Filamin Binding to Integrin Beta Cytoplasmic Domains Inhbits Membrane Protrusion, Cell Polarization, and Cell Migration. Nature Cell Biology 12:1060.

   35. Calderwood, D.A., Zent, R., Grant, R., Rees, D.J.G., Hynes, R.O., and Ginsberg, M.H. 1999. The talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation. Journal of Biological Chemistry 274:28071.

   36. Liu, S., Thomas, S.M., Woodside, D.G., Rose, D.M., Kiosses, W.B., Pfaff, M., and Ginsberg, M.H. 1999. Paxillin binding to alpha 4 integrins modifies integrin-dependent biological responses. Nature 402:676.

   37. Pfaff, M., Liu, S., Erle, D.J., and Ginsberg, M.H. 1998. Integrin beta cytoplasmic domains differentially bind to cytoskeletal proteins. Journal of Biological Chemistry 273:6104.

   38. Fenczik, C.A., Sethi, T., Ramos, J.W., Hughes, P.E., and Ginsberg, M.H. 1997. Complementation of dominant suppression implicates CD98 in integrin activation. Nature 370:81.

   39. Hughes, P.E., Renshaw, M.W., Pfaff, M., Forsyth, J., Keivens, V.M., Schwartz, M.A., and Ginsberg, M.H. 1997. Suppression of integrin activation: A novel function of a Ras/Raf-initiated MAP kinase pathway. Cell 88:521.

   40. Palecek, S.P., Loftus, J.C., Ginsberg, M.H., Horwitz, A.F., and Lauffenburger, D.A. 1997. Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness. Nature 385:537.

   41. Hughes, P.E., Diaz-Gonzalez, F., Leong, L., Wu, C., McDonald, J.A., Shattil, S.J., and Ginsberg, M.H. 1996. Breaking the integrin hinge: a defined structural constraint regulates integrin signaling. Journal of Biological Chemistry 271:6571.

   42.       Wu, C., Keivens, V.M., O'Toole, T.E., McDonald, J.A., and Ginsberg, M.H. 1995. Integrin activation and cytoskeletal interaction are essential for the assembly of a fibronectin matrix. Cell 83:715.