• 1976 - M.D., Ch.B. (Medicine), University of Cape Town South Africa
  
• 1984 - Post-doc (Allergy/Immunology), University of California, San Diego

• 1977 - 1978: Internship (Rotating)
• Groote Schuur Hospital, Cape Town, South Africa
• 1978 - 1981: Residency (Internal Medicine), Harvard Clinical Fellow in Medicine
• Peter Bent Brigham-Waltham Hospital Program, Boston, MA
• 1981 - 1982: Chief Resident (Internal Medicine), Harvard Clinical Fellow in Medicine
• Brigham and Women’s-Waltham Hospital Program, Boston, MA
• 1983 - 1984: General Internal Medicine
• Harvard University Health Service/Milford Hospital, Boston
• 1984 - 1987: Postdoctoral Fellow, Division of Allergy/Immunology
• University of California, San Diego, CA
• 1987 - 1995: Assistant Professor of Medicine In Residence
• University of California, San Diego, CA
• 1995 - 2002: Associate Professor of Medicine In Residence
• University of California, San Diego, CA
• 2002 - 2004: Professor of Medicine In Residence
• University of California, San Diego, CA
• 2004 - Present: Professor of Medicine
• University of California, San Diego, CA

• Allergy & Immunology
• Internal Medicine

• UCSD Thornton Hospital, La Jolla
• UCSD Medical Center, Hillcrest

• 1994: Charles Reed Lectureship, American Academy of Allergy and Immunology
• 1998 - Present: Best Doctors in America
• 1999: Presidential Symposium Lecture, American Academy of Asthma, Allergy, Immunology
• 1995 - 2000: Editorial Board, Journal of Allergy and Clinical Immunology
• 1994 - 1997: VA Immunology Study Section Member
• 1996 - 1997: Chairman, VA Immunology Study Section
• 1996 - 2000: NIH, Study Section Member (Allergy, Immunology and Transplantation) NIAID
• 2000 - 2005: Director, American Board of Allergy and Immunology
• 2003: Hal Nelson Lectureship, American Academy of Asthma, Allergy and Immunology
• 2002 - Present: NIH Immune Tolerance Network: Asthma Subgroup Co-Leader
• 2000 - 2007: Section Editor, Current Opinions in Allergy and Clinical Immunology
• 2001 - Present: Section Editor, Clinical Immunology
• 2007 - Present: Associate Editor, Journal Allergy Clinical Immunology
• 2007-2012: NIH MERIT Award
• 2008: Association of American Physicians (AAP)

• Asthma
• Sinus Allergy
• Allergen Immunotherapy
• Anaphylaxis

(Publications selected from 105 manuscripts)

1.    Broide DH and GS Firestein.  Endobronchial allergen challenge in asthma.  Identification of cellular source of GM-CSF by in situ hybridization.  J Clin Invest, 88:1048 (1991).

2.    Broide DH, MM Paine, and GS Firestein.  Eosinophils express Interleukin 5 and granulocyte macrophage-colony-stimulating factor mRNA at sites of allergic inflammation in asthmatics.  J Clin Invest, 90:1414-1424 (1992).

3.    Sriramarao P, UH Von Andrian, EC Butcher, MA Bourdon and DH Broide.  a4b1, integrin and L-selectin mediate eosinophil rolling at physiological shear rates in-vivo. J Immunol 153:4238 (1994).

4.    Sriramarao P, CR Norton, P Borgstrom, R DiScipio, BA Wolitzky and DH Broide.  E-selectin preferentially supports neutrophil but not eosinophil rolling under conditions of flow in vitro and invivo.  J. Immunol, 157:4672-4680 (1996).

5.    Sung KLP, L Yang, M Elices, G Jin, P Sriramarao, and DH Broide.  GM-CSF regulates the functional adhesive state of VLA-4 expressed by eosinophils.  J. Immunol, 158:919-927 (1997).

6.    Broide DH, S Sullivan, T Gifford, and P Sriramarao. Inhibition of pulmonary eosinophilia in P-selectin and ICAM-1 deficient mice.  Am J. Resp. Cell Mol Biol.,18:218-225 (1998).

7.    Broide DH, D Humber, S Sullivan, and P Sriramarao. Inhibition of eosinophil rolling and recruitment in P-selectin and ICAM deficient mice.  Blood, 91:2847 (1998).

8.    Broide DH, J Schwarze, H Tighe, T Gifford, MD Nguyen, S Malek, J Van Uden, EW Gelfand, E Raz Immuno-stimulatory CpG DNA Sequences Inhibit IL-5, Eosinophilic Inflammation, and Airway Hyperresponsiveness in Mice. J Immunol,161:7054-7062 (1998).

9.    Broide DH, H Hoffman, and P Sriramarao. Genes that regulate eosinophilic inflammation. Am J. Human Genetics. 65:302-307 (1999).

10.   Broide DH, T Gifford, K Campbell, and P Sriramarao. Inhibition of Eosinophilic Inflammation in Allergen Challenged IL-1-Receptor Type I Deficient Mice is Associated with Reduced Eosinophil Rolling and Adhesion on Vascular Endothelium.  Blood, 95:263-269 (2000).

11.   Sriramarao P, R DiScipio, R Cobb, M Cybulsky, G Stachnick, D Castaneda, M Elices, and DH Broide. VCAM-1 is more effective than MAdCAM-1 in supporting eosinophil rolling under conditions of shear flow.  Blood, 95:592-601 (2000).

12.   Broide DH , G Stachnick, D Casteneda, J Nayar, and P Sriramarao. Inhibition of Eosinophilic Inflammation in Allergen Challenged TNF-Receptor p55/P75 and TNF Receptor p55 Deficient Mice. Am J Resp Cell Mol Biol 24:304-311 (2001).

13.   Berin, CM, L Eckmann, DH Broide, MF Kagnoff. Regulated production of the Th2-type T cell chemoattractant TARC by human bronchial epithelial cells in vitro and in human lung xenografts.  Am J Resp Cell Mol Biol 24:382-389 (2001)

14.   Miller M, Sung KL, WA Muller, Cho JY, Roman M, Castaneda D, J Nayar,  Condon T, Kim J, Sriramarao P, and DH Broide. Eosinophil tissue recruitment to sites of allergic inflammation in the lung is platelet endothelial cell adhesion molecule independent. J Immunol 167:2292-2297 (2001).

15.   Hoffman HM, Mueller JL, Broide DH, Wanderer AA, Kolodner RD. Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nature Genetics 29:301-305 (2001).

16.   Broide DH, G Stachnick, D Castaneda, J Nayar, M Miller, JY Cho, M Roman, Ellies LG, and P Sriramarao. Core 2 oligosaccharides mediate eosinophil and neutrophil peritoneal but not lung recruitment. Am J Physiol Lung Cell Mol Physiol. 282:L259-266 (2002).

17.   Khaldoyanidi S, L Sikora, DH Broide,  ME Rothenberg, P Sriramarao. Constitutive over expression of IL-5 induces extramedullary hematopoiesis in the spleen. Blood 101:863-868 (2003).

18.   Ikeda RK, J Nayar, JY Cho, M Miller, M Rodriguez, E Raz, and DH Broide. Resolution of inflammation following ova inhalation: Comparison of ISS DNA and corticosteroids. Am J Resp Cell Mol Biol 28:655-663 (2003).

19. Ikeda RK, Miller M, Nayar J, Walker L, Cho JY, McElwain K, McElwain S, Raz E, Broide DH. Accumulation of peribronchial mast cells in a mouse model of ovalbumin allergen induced chronic airway inflammation: modulation by immunostimulatory DNA sequences. J Immunol. 171:4860-7(2003).

20.   Holgate S, and Broide DH. New targets for allergic rhinitis-a disease of civilization. Nature Rev Drug Discov. 2: 902-14.(2003).

21.   Hayashi T, Beck L, Rossetto C, Gong X, Takabayashi K, Broide DH, Carson DA, Raz E. Inhibition of experimental asthma by indoleamine 2,3-dioxygenase. J Clin Invest. 114:270-9. (2004)

22. Cho JY, Miller M, Baek, KJ, Han JW, Nayar J, Rodriguez M, Lee SY, McElwain K, McElwain S, Raz E, and Broide DH. Immunostimulatory DNA inhibits TGF-beta expression and airway remodeling. Am J Respir Cell Mol Biol. 30:651-661. (2004)

23. Cho JY, Miller M, Baek, KJ, Han JW, Nayar J, Rodriguez M, Lee SY, McElwain K, McElwain S, Friedman S, and Broide DH. Inhibition of airway remodeling in IL-5 deficient mice. J Clin Invest. 113:551-60. (2004).

24.Cho JY, Miller M, Baek KJ, Han JW, Nayar J, Rodriguez M, Lee SY, McElwain K, McElwain S, Raz E, Broide DH. Immunostimulatory DNA reverses allergen induced airway remodeling. J Immunol. 173:7556-64. (2004). 

25. Broide DH, Lawrence T, Doherty T, Cho JY, Miller M, McElwain K, McElwain S, M Karin. Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epithelium .Proc Natl Acad Sci U S A. 102:17723-17728 (2005).

26. Creticos PS, Schroeder JT, Hamilton RG, Balcer-Whaley SL, Khattignavong AP,  Lindblad R, Li H, Coffman R, Seyfert V, Eiden JJ, Broide D and the Immune Tolerance Network Group. Immunotherapy with a Ragweed-TLR9 Agonist Vaccine for allergic rhinitis. New Eng J Med 355:1445-1455 (2006).

27.  Zhang M, Angata T, Cho Jy, Miller M, Broide DH, Varki A. Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils. Blood. 109: 4280-4287 (2007).

28.  Min MG, Song DJ, Miller M, Cho JY, McElwain S, Ferguson P, Broide DH. Coexposure to environmental tobacco smoke increases levels of allergen induced airway remodeling in mice. J Immunol 178:5321-5328 (2007).

29.  Le AV, Cho JY, Miller M, McElwain S, Golgotiu K, Broide DH. Inhibition of allergen induced airway remodeling in Smad3 deficient mice. J Immunol  178: 7310-7316 (2007).

30.  Hayashi T, Mo JH, Gong X, Rossetto C, Jang A, Beck I, Elliot GI, Kufareva I, Abagyan R, Broide DH, Lee J, Raz E. 3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis. Proc Natl Acad Sci USA 104: 18619-24 (2007).

31.  Fong CH, Bebien M, Sisierlaurent A Newbauer R, Hussell T, Broide D, Karin M, Lawrence T. An anti-inflammatory role for IKKbeta through the inhibition of “classical” macrophage activation. J Exp Med 205: 1269-76 (2008).

32.  Miller M, Cho JY, Pham A, Ramsdell J, Broide DH. Adiponectin and functional adiponectin receptor 1 are expressed by airway epithelial cells in COPD. J Immunol (2008) In press.